Join to view profile Biosplice Therapeutics . Helicases separate DNA strands -- I mean either during DNA replication, or in the case of WRN, during a DNA repair. Cost basis and return based on previous market day close. Issi Rozen is as deeply embedded into the gene editing field as anyone in the buzzy Cambridge, MA biotech hub. Biosplice's mission is to restore health by delivering first-in-class therapies that harness alternative splicing. By accessing this site and any pages thereof, you agree to be bound by our Terms of Use.EquityZen and logo are trademarks of EquityZen Inc. Other trademarks are property of their respective owners. 2023 EquityZen Inc. All rights reserved. Stemming from foundational discoveries in Wnt pathway. Stemming from foundational discoveries in Wnt pathway modulation, Biosplice has elucidated novel biology linking CLK/DYRK kinases to the therapeutic regulation of alternative splicing. Each of these companies announced their intentions this week. Jan 3, 2023 06:30am. This week began with four biopharma companies announcing intentions to become publicly traded companies and its ending with three companies making their debut on the Nasdaq. Edgewises lead drug candidate is EDG-5506, an orally administered small molecule designed to address the root cause of dystrophinopathies, in development for the treatment of Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy (DMD). The company is headquartered in San Diego, California. Equity securities are offered through EquityZen Securities. Ikena Oncology, a company focused on developing cancer therapies targeting key signaling pathways that drive the formation and spread of cancer, begins trading on the Nasdaq at $16 per share. Ikena has entered into a global strategic collaboration with Bristol Myers Squibb on the IK-175 and IK-412 programs. SAN DIEGO, Jan. 27, 2022 /PRNewswire/ -- Biosplice Therapeutics, Inc., a clinical-stage biotechnology company pioneering therapeutics based on CLK/DYRK kinase modulation for major diseases, and . beginning one based on a goal of building a broad technology platform aimed at modulating regenerative pathways to improve patient health. Just weeks after activist investor Alex Denner called for Amarins chairman to step down, the Irish biotechs shareholders have voted in Denners favor. Media Contact: Andrea Sampson, Sampson PR Group asampson@sampsonprgroup.com, 562-304-0301 Investor Contact: Jody Cain, LHA Investor Relations Jcain@lhai.com, 310-691-7100 If you're already an Endpoints subscriber, enter your email below for a San Diego, California, United States. Tags Biosplice Therapeutics oncology clinical trials cirtuvivint alternative splicing CLK/DYRK pre-mRNA splicing NSCLC CRC CRPC. "Mr. Johnson's vast experience ushering drugs from . Biosplice Therapeutics is an American pharmaceutical company engaged in the development of alternative splicing technologies. The malignant cells permeated his bones, kidney, lungs and liver, and in December, his oncologist told him there was no point in continuing chemotherapy treatment. Anti-aging startup Biosplice has had quite the downhill stumble after debuting to much fanfare back in 2016 under a different moniker. With their platform's origins in small molecule-based Wnt pathway modulation, they develop therapeutics to address a range of degenerative diseases, regenerative medicine, and oncology. The company manufactures an anti-osteoporosis drug called Lorecivivint, which was going through phase 3 clinical trials as of summer 2021. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services. Check the background of this firm on FINRAs BrokerCheck. It might be worth that much, but on a risk-adjusted basis, I just don't know. Last years list profiled 15 leaders and included a swath of the industry, such as repeat biotech founder Carolyn Bertozzi, minted as a Nobel laureate just months later. Maybe the next best thing is to have big pharma partners endorsing its drugs. In December, Edgewise raised $95 million in a Series C financing round. Chief Financial Officer and Chief Business Officer of Biosplice Therapeutics, Inc. San Diego County, California, United States. In January, the company secured $120 million in a Series B financing round. Novartis can't make enough of it, A gene editing 3.0 player goes deep on cash, frontier science to put precision epigenetics to the big test, Decades after breakthrough, scientists still puzzling over mRNA delivery, Following the government's lead, Lilly caps out-of-pocket costs for insulin at $35 per month, Cell therapy biotech from Stanford CAR-T leader Crystal Mackall nabs $200M for PhII, Ex-AveXis crew trims staff at Chicago-area Jaguar Gene Therapy, Keytruda hits one primary endpoint for use before and after surgery in lung cancer, Amicus eyes Pompe approval; Atea ends Dengue work; 2seventy, Travere line up offerings. a short wikipedia entry. CIOs and business technology executives at this event will also discuss how men Shanghai Everest Medicines in-licensed a BTK inhibitor for renal diseases from Sinovent and SinoMab Bio for $561 mln. Like the other two companies, Edgewise Therapeutics recently conducted a financial raise. magic link that lets you log in quickly without using a password. Join to connect . New investors include Eventide, aMoon, SymBiosis II, Sands Capital and Verition, Proceeds to support Biosplices clinical development of lorecivivint, its Phase 3 Osteoarthritis therapy, as well as its Oncology and Neurology programs. In September 2020, Sorrento Therapeutics released positive Phase 1b trial data (clinicaltrials.gov NCT03542838) of resiniferatoxin (RTX) in the reduction of OsteoArthritis (OA) knee pain. https://www.streetinsider.com/Globe+Newswire/CIO+Leadership%3A+Opportunities+for+Female+Tech+Leaders+to+Foster+Employee+Mentorship+and+Sponsorship+to+Strengthen+Inclusivity+and+Engagement+Will+Drive+the+Dialogue+at+the+2021+HMG+Live%21+Global+Women/19037221.html, https://seekingalpha.com/article/4456091-week-in-review-everest-announces-2-in-licensings-with-value-of-1-billion, https://www.benzinga.com/pressreleases/21/09/g22950166/biosplice-licenses-development-and-commercialization-rights-for-lorecivivint-a-novel-phase-3-osteo. The Motley Fool owns shares of and recommends Bristol Myers Squibb. As chief business officer and strategy chief for the Broad over a decade-long stretch, hed worked with all the big names in a scientific discipline that promises to upend the therapeutics field eventually. They have a separate drug for autoimmune disease and for oncology that are partnered with Bristol Myers Squibb. Ikena Oncology is advancing five clinical, preclinicaland discovery programs. That's especially the case with biotech stocks that go public. *** - To view the data, please log into your account or create a new one. Nominate them for Endpoints annual report, Keytruda hits one primary endpoint for use before and after surgery in lung cancer. Other disorders the company will target with its GeneTac platform will include myotonic dystrophy type-1, and other indications that have yet to be publicly announced. Eli Lilly is looking to get ahead of any more federal action on insulin prices, announcing today that it will not only slash its most commonly used insulin by 70%, but cap out-of-pocket costs for those on commercial insurance at $35 per month just as the federal government recently did for those insured by Medicare. Vividion Therapeutics has filed to go public. Biosplice Therapeutics, Inc. SAN DIEGO, April 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. (Biosplice), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing for major diseases, announced today it has closed $120 million in equity financing from a new biotechnology investment syndicate. They also plan to go public with an IPO this year. Gerostate Alpha raising $500k through WeFunder (Live Now). David Ricks, Eli Lilly CEO (David Paul Morris/Bloomberg via Getty Images), Catherine Stehman-Breen, Chroma Medicine CEO, Alex Denner (Mark Neuling/CNBC/NBCU Photo Bank via Getty Images), Hemolytic Anemia Sales Specialist, Rare Genetic Diseases, Biosplice, a former anti-aging unicorn, slashes staff in latest episode of its long fall from grace, Digital therapeutics: The key to maximizing the potential of medicinal assets, A radioactive prostate cancer therapy is a last lifeline for patients. X0002 is . The Website is reserved exclusively for non-U.S. Other biopharma companies will soon make their debut on stock exchanges. Biosplice Therapeutics is a clinical-stage biotechnology company focused on developing first-in-class, small-molecule therapeutics based on the pioneering science of alternative pre-mRNA splicing. Samumed made quite the entrance back in 2016, when it launched with some anti-aging programs and a whopping $12 billion valuation. Design said it expects to raise approximately $240 million from the IPO, a little bit higher than the $228 million the company previously anticipated. SAN DIEGO, June 21, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics ("Biosplice"), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing for major diseases, announced today the addition of Dave Johnson, most recently Founder and CEO of VelosBio, as an independent director to its board. Biosplice Therapeutics has produced fresh biological insights and unique chemical equity that delivers therapeutic modulation of alternative splicing by targeting the CLK/DYRK family kinases. The move to again slash the cost of insulin back in 2019, Lilly cut the list price of Humalog by 50% comes as rationing of the life-saving shot has led to deaths for some diabetics who could not afford their injections, even as Congress is working on another push to cap out-of-pocket costs for diabetics after Senate Republicans shot down the idea last August. We are particularly excited by lorecivivint, which has the potential to be a first-in-class medicine that could confer both symptomatic and disease-modifying benefits to hundreds of millions of osteoarthritis sufferers worldwide.. Register today to connect with our Private Market Specialists and learn more about new pre-IPO investment opportunities. Amicus said last October the FDA wasnt able to do the required inspection of its manufacturing partner, WuXi Biologics in China, during the review timeframe because of restrictions on travel related to the pandemic. Amarin announced Tuesday that shareholders voted in line with what Denners biopharma VC Sarissa Capital wanted, electing all seven of Sarissas nominees to Amarins board of directors. . Please note the magic link is Mammoth Biosciences is a developer of a CRISPR platform for diagnostic, genome editing, and protein discovery applications. Biosplice Therapeutics is a private company and not publicly traded. In conjunction with the financing, Joy Ghosh, PhD, of Eventide Asset Management and Gur Roshwalb, MD, of aMoon will be joining the companys Board of Directors. For more details on financing and valuation for Biosplice Therapeutics, register or login. After Novartis acquired AveXis, executives from the leading gene therapy biotech shuffled off to form new startups looking to repeat their Zolgensma story for other diseases. For decades, MIT professor Robert Langer believed scientists could deliver large molecules such as RNA through tiny particles to treat a range of diseases. Biosplice Therapeutics is funded by 11 investors. The data in the chart above is based on data derived from our proprietary XP calculation model and may be changed, adjusted and updated without prior notice. Brian Orelli: IPOs lately have been really early-stage. When he told a group of senior scientists about his ideas for drug delivery at a Chinese restaurant in 1979, one of them blew cigar smoke in his face. Samumed is in the medical research and development for tissue-level regeneration. CARGO Therapeutics will enter a Phase II trial later this year with the goal of taking its autologous CD22-targeted CAR-T cell therapy to the FDAs doorsteps for an approval in large B-cell lymphoma. Stemming from foundational discoveries in Wnt pathway. Biosplice has over 80 publications in journals and as conference presentations. Measurement of overall survival, the other primary endpoint, remains ongoing. The approval request includes both a BLA and NDA. Funds from the IPO and the Series B will support development of the companys oncology pipeline. Total amount raised across all funding rounds, Total number of Crunchbase contacts associated with this organization, Total number of employee profiles an organization has on Crunchbase, Total number of investment firms and individual investors, Total number of organizations similar to the given organization, Descriptive keyword for an Organization (e.g. EquityZen.com is a website operated by EquityZen Inc. ("EquityZen"). Founded in 1993 by brothers Tom and David Gardner, The Motley Fool helps millions of people attain financial freedom through our website, podcasts, books, newspaper column, radio show, and premium investing services. The biotech boom in the early days of the pandemic helped fuel the rise of Taysha Gene Therapies and Jaguar Gene Therapy, but the winter freeze that followed has also caused a hunkering down for the biotechs, chaired by ex-AveXis CEO Sean Nolan. We are particularly excited by lorecivivint, which has the potential to be a first-in-class medicine that could confer both symptomatic and disease-modifying benefits to hundreds of millions of osteoarthritis sufferers worldwide.. The information provided on Xipometer.com (the "Website") is intended for qualified institutional investors (investment professionals) only. Biosplice Therapeutics (formerly Samumed) "Biosplice's mission is to restore health by delivering first-in-class therapies that harness alternative splicing.". 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